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KMID : 1007520210300040583
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Food Science and Biotechnology
2021 Volume.30 No. 4 p.583 ~ p.588
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Combination of vegetable soup and glucan demonstrates synergistic effects on macrophage-mediated immune responses
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Lee Ha-Nul
Choi Joo-Hee
Park Ji-Yeon
Ahn Jae-Hun
Jang Da-Eun
Shim Jae-Gun
Park Jong-Hwan
Kim Young-Min
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Abstract
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Vegetable soup (VS), a plant-based functional food, has been used as a traditional folk medicine and is attracting attention for its ability to enhance the immune response. β-Glucan, a well-established and effective immunomodulator, has synergistic effects when used in combination with some bioactive compounds. In the present study, we aimed to evaluate the synergistic immunomodulatory effects of the combination of VS and β-glucan on macrophage-mediated immune responses. β-Glucan was demonstrated to synergistically enhance the VS-stimulated immune response, including the production of interleukin-6, tumor necrosis factor-α, and nitric oxide, mainly through the mitogen-activated protein kinase pathway in macrophages. In addition, this combination has the potential for further development in functional foods with immune-enhancing activity.
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KEYWORD
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Vegetable soup, β-glucan, Synergistic effect, Mitogen-activated protein kinase, Immune response
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